Harvard Medical School

Contact Information:

Evergrande Center for Immunologic Diseases
Harvard Medical School
Building for Transformative Medicine (BTM),
Room 9016AA
60 Fenwood Road, Boston, MA 02215

Office (617) 525-3066


Research Summary

Our lab studies the immune signaling pathways that support tissue integrity, and the mechanistic basis for tissue dysregulation in inflammatory disorders and cancer. The questions we pursue are grounded in understanding the interplay between tissue physiology and the innate immune system, as a central axis controlling homeostasis and disease. A major focus of the lab is the immunoregulatory roles of the non-immune cellular compartment comprising epithelial, vascular and stromal cells, in the development of pathological inflammation. We use advanced mouse models and imaging platforms, genome editing tools and a variety of molecular and cellular techniques to investigate immune signaling within tissues and to discover the factors that impact the tissue microenvironment in inflammation and cancer. Our mission is to identify effective therapeutic targets for restoring tissue integrity in immune-related disorders.

To learn more, visit our lab website: https://www.nowarskilab.com/

Selected Publications

Nowarski, R., R. Jackson, and R. A. Flavell. 2017. The Stromal Intervention: Regulation of Immunity and Inflammation at the Epithelial-Mesenchymal Barrier. Cell 168: 362-375.

Nowarski, R., R. Jackson, N. Gagliani, M. R. de Zoete, N. W. Palm, W. Bailis, J. S. Low, C. C. Harman, M. Graham, E. Elinav, and R. A. Flavell. 2015. Epithelial IL-18 Equilibrium Controls Barrier Function in Colitis. Cell 163: 1444-1456.

Wlodarska, M., C. A. Thaiss, R. Nowarski, J. Henao-Mejia, J. P. Zhang, E. M. Brown, G. Frankel, M. Levy, M. N. Katz, W. M. Philbrick, E. Elinav, B. B. Finlay, and R. A. Flavell. 2014. NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell 156: 1045-1059.

Elinav, E., R. Nowarski, C. A. Thaiss, B. Hu, C. Jin, and R. A. Flavell. 2013. Inflammation-induced cancer: crosstalk between tumours, immune cells and microorganisms.
Nature reviews. Cancer 13: 759-771.