Ragon Institute of MGH, MIT and Harvard
400 Technology Square
Cambridge, MA 02139
Our research focuses on the development of adaptive immune responses, protein evolution and the interactions between host and pathogen using a combination of biophysical, biochemical and molecular virology techniques. We are structural biologists who bring mechanistic and quantitative approaches to address fundamental problems in virology and immunology. We primarily study orthomyxo- and flaviviruses but our interests extend to emerging viruses (e.g. alpha-, arena-, bunya- and filoviruses) and other pathogens. We are strong believers in collaboration and are always open to pursuing new directions and pathogens.
McCarthy KR, Watanabe A, Kuraoka M, Do KT, McGee CE, Sempowski GD, Schmidt AG, Kelsoe G, Harrison SC (2017) Human Memory B cells The Cross-React with Group 1 and Group 2 Influenza A Viruses. Immunity. 48: 174-184
Raymond DD, Bajic G, Ferdman J, Suphaphiphat P, Settembre E, Moody MA, Schmidt AG, Harrison SC. (2018) Conserved epitope on influenza-virus hemagglutinin head defined by a vaccine-induced antibody. PNAS 17154711: 1-6.
Raymond DD, Stewart S, Lee J, Ferdman J, Bajic G, Do KT, Ernandes MJ, Suphaphiphat P, Settembre EC, Dormitzer PR, Del Giudice G, Finco O, Kang TH, Ippolito GC, Georgiou G, Kepler TB, Haynes BF, Moody MA, Liao H-X, Schmidt AG, Harrison SC (2016) Influenza immunization elicits hemagglutinin receptor-site antibodies specific for an egg-adapted vaccine strain. Nature Medicine. 10.1038: 1-7.
Kuraoka M, Schmidt AG, Nojima, T, Feng F, Watanabe A, Kitamura D, Harrison SC, Kepler TB and Kelsoe G (2016) B-cell selection in germinal centers elicited by complex antigens. Immunity, 44 1-11.
Schmidt AG, Khoi KT, McCarthy KR, Kepler TB, Liao HX, Moody MA, Haynes BF and Harrison SC (2015) Immunogenic stimulus for germline precursors of influenza-specific antibodies Cell Reports, 13 2842-50.
Schmidt AG, Therkelsen MD, Stewart S, Kepler TB, Liao HX, Moody MA, Haynes BF and Harrison SC (2015) Viral receptor-binding site antibodies with diverse germline origins. Cell 161 1026-34.
Schmidt AG*, Xu H*, Khan AR, O’Donnell T, Khurana S, King LR, Manischewitz J, Golding H, P. Suphaphiphat P, Carfi, A, Settembre EC, Dormitzer PR, Kepler TB, Zhang R-J, Moody MA, Haynes BF, Liao HX, Shaw DE and Harrison SC (2013) Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza antibody PNAS 110 (1) 264-269.
Schmidt AG, Lee K, Yang PL and Harrison SC (2012) Small-molecule inhibitors of dengue-virus entry. PLoS Pathogens 8 (4): 1-10.
Schmidt AG, Yang PL and Harrison SC (2010) Peptide inhibitors of flavivirus entry derived from the E protein stem. J Virol. 2010 Dec; 84 (24):12549-54.
Schmidt AG, Yang PL, and Harrison SC (2010). Peptide Inhibitors of Dengue-Virus Entry Target a Late Stage Fusion Intermediate. PLoS Pathogens (6 ) 4.