Microbiology 201:
Molecular Biology of the Bacterial Cell

Spring Semester 2017
Tuesday and Thursday from 10:00am to 12:00 noon


This course is devoted to bacterial structure, physiology, genetics, and regulatory mechanisms. The class consists of lectures and group discussions emphasizing methods, results, and interpretations of classic and contemporary literature.

Instructors: David Rudner, Thomas Bernhardt, Ann Hochschild, Simon Dove

Rudner: rudner@hms.harvard.edu (432-4455)
Bernhardt: thomas_bernhardt@hms.harvard.edu (617-466-9851)
Hochschild: ann_hochschild@hms.harvard.edu (432-1986)
Dove: simon.dove@childrens.harvard.edu (919-2888)

Time: Tuesday & Thursday 10am-12:00pm
Location: NRB1031

If you need to miss class, let the current lecturer and curriculum fellow know in advance.
Absences for which you don’t let us know in advance (barring emergency) will result in a reduced participation grade.

If you miss more than one class, you will be asked to write a 1-page (single-space) summary of the assigned papers you missed.


Date Class Instructor Topic Required Reading Background Reading Extra
01/24 Class 1 Bernhardt Protein Secretion and the Sec system
01/26 Class 2 Bernhardt The cell envelope and lipoprotein transport
01/31 Class 3 Bernhardt Envelope stress responses
02/02 Class 4 Bernhardt Peptidoglycan and cell shape determination
02/07 Class 5 Bernhardt Cell division and its control
4, 5
02/09 Class 6 Bernhardt Cell motility and trans-envelope machines
3, 4
02/14 Class 7 Bernhardt Phage vs. Host
4, 5
Problem set handed out
02/16 Class 8 Dove Transcription and its regulation
02/21 Class 9 Dove Transcription and its regulation continued
02/23 Class 10 Dove RNA degradation
02/28 Class 11 Dove Small RNAs
03/02 Class 12 Dove Small RNAs continued
03/07 Class 13 Dove Second messengers
03/09 Class 14 Dove Bistability and phase variation
Problem set handed out
spring break
03/21 Class 15 Rudner DNA replication and its control
03/23 Class 16 Rudner Plasmids and their segregation
03/28 Class 17 Rudner Chromosome organization/segregation
03/30 Class 18 Rudner Toxin-antitoxin (TA) systems
04/04 Class 19 Rudner Cell-cell Signaling
04/06 Class 20 Rudner Checkpoints
04/11 Class 21 Rudner Development
Problem set handed out
04/13 Class 22 Dove Translation and protein degradation
04/18 Class 23 Dove  
04/20 Class 24 Dove  
04/25 Class 25 Danielle  
04/27 Class 26 Danielle  
05/02 Class 27 Danielle  
05/04 Class 28 Danielle  

Problem set handed out