Microbiology 214:
Mechanisms of Bacterial Pathogenesis and Host Immune Response

Harvard Medical School, Fall 2018
Tuesdays and Thursdays
10:00am to 12:00 noon

NRB 1031

Marcia Goldberg, MD (Course director, marcia.goldberg@mgh.harvard.edu); Min Dong, PhD; Darren Higgins, PhD; Jonathan Kagan, PhD; Michael Starnbach, PhD; Deepali Ravel, PhD (Curriculum Fellow, deepali_ravel@hms.harvard.edu)

Syllabus

 
Date
Instructor
Topic
Required
Background
2
9/4/18
Goldberg Mechanisms of entry using type 3 secretion
1, 2
3, 4, 5
3
9/6/18
Goldberg Type 3 secretion disruption of host signaling pathways
1, 2
3, 4
4
9/11/18
Goldberg

Cellular trafficking and type 3 and 4 secretion systems

1, 2
3, 4
5
9/13/18
Goldberg

Mechanisms of antibiotics and approaches to antibiotic discovery

1, 2, 3
4, 5
6
9/18/18
Kagan

Mechanisms of living in a vacuole

1, 2
7
9/20/18
Starnbach

Overview of immune response to pathogens (innate and adaptive)

1, 2
 
8
9/25/18
Kagan

Toll-like receptors

1, 2
3, info 1 2 3
9
9/27/18
Kagan

Inflammasome activation

10
10/2/18
Kagan

Disease tolerance

1, 2, 2s
11
10/4/18
Kagan

Manipulation of MAP kinase pathways

12
10/9/18
Kagan

NFKB signaling

1, 2, 2s

Problem Set 1 assigned 10/9/2018, due 10/15/2018

13
10/11/18
Starnbach

Alteration of host ubiquitination

1, 2, 3
14
10/16/18
Ravel

Bacterial killing via type 6 secretion systems

1, 1s, 2, 2s
3, 4
15
10/18/18
Starnbach

Autophagy

1, 1s, 2
16
10/23/18
Ravel

Host-pathogen-microbiota interactions

1, 2
17
10/25/18
Dong

Other bacterial toxins

1, 2
3, 4
18
10/30/18
Starnbach

Regulation of chronic infection I

1, 2
19
11/1/18
Starnbach

Regulation of chronic infection II

1, 2
20
11/6/18
Starnbach

Bacterial manipulation of adaptive immunity

1, 2
21
11/8/18
Higgins

Mechanisms of entry into cells (non-type 3 secretion mediated)

1, 1s, 2
22
11/13/18
Higgins

Actin-based motility

1, 2
23
11/15/18
Higgins

Bacteria and apoptosis

1, 2, 3
24
11/20/18
Higgins

Biofilms

11/22/18
Thanksgiving break
25
11/27/18
Higgins

Vaccine development and adjuvants I

3, 4
26
11/29/18
Higgins Vaccine development and adjuvants II
1, 2, 2s

Problem Set 2 assigned 11/29/2018, due 12/6/2018

Course Website: http://micro.med.harvard.edu/pages/micro214.html

Readings will be posted on the course website. You are expected to have thoroughly read the assigned papers before arriving at class.